Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Glycyl-Exatecan (TFA) | 1883333-57-0 | 96.9% | 25 MG
Glycyl-Exatecan TFA (Glycyl-DX-8951 TFA) is an anticancer agent and a derivative of Exatecan. It exhibits significant antitumor activity and is suitable for research on various cancers, including solid tumors.
- Derivative of Exatecan
- Anticancer agent
- Exhibits significant antitumor activity
- Suitable for research on various cancers
- Can be used for solid tumors research
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.68% | 871.94 | 1 ML
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. It has been shown to increase circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, particularly in high-fat-fed mice. This compound is suitable for use in type 2 diabetes research. It is intended for research use only and is not sold to patients.
- Potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM.
- Increases circulating insulin in high-fat-fed mice.
- Enhances glucose tolerance to oral glucose.
- Suitable for use in type 2 diabetes research.
- Intended for research use only.
Medchemexpress LLC F9170 (TFA) | 99.7% | 1983.3 g/mol | 5 MG
F9170 (TFA) is a laboratory chemical with 99.7% purity and a molecular weight of 1983.3 g/mol. It appears as a solid and is stable under recommended storage conditions. This product is intended for research use only and should be handled by suitably qualified and experienced scientists in appropriate facilities.
- Solid appearance
- Stable under recommended storage conditions
- Store powder at -80°C for up to 2 years or -20°C for up to 1 year
- Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month (sealed storage, away from moisture)
- Suitable for shipping at room temperature if less than 2 weeks
- Requires handling in areas with appropriate exhaust ventilation
- Keep container tightly sealed in a cool, well-ventilated area
- Keep away from direct sunlight and sources of ignition
Medchemexpress LLC Alvespimycin trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g/mol | C34H49F3N4O10 | 1 MG
Alvespimycin TFA is the trifluoroacetate salt of 17-DMAG, a small-molecule Hsp90 inhibitor used in research to probe Hsp90 biology, induce client protein degradation, and trigger stress responses in cancer cell models.
- Potent Hsp90 inhibition with low-nanomolar cellular activity.
- Promotes degradation of Hsp90 client proteins, including Her2.
- Induces Hsp70 expression and apoptosis in sensitive cancer cells.
- High purity solid suitable for biochemical and cellular assays.
- Available in small research quantities for dose-response studies.
- Stable when stored sealed at recommended temperatures.
Medchemexpress LLC LL-37 amide (TFA) | 99.34% | 4492.28 | 5 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens. It exerts bactericidal effects by activating immune cell chemotaxis and disrupting bacterial cell membrane integrity. This peptide also regulates inflammatory responses and promotes angiogenesis. Its amidation modification reduces sensitivity to serum inhibition and improves stability, making it suitable for research on infection-related diseases like periodontal disease, deep tissue injuries, and wound healing.
- Selective agonist of formyl peptide receptor-like FPRL1
- Inhibits periodontal pathogens
- Exerts bactericidal effects
- Regulates inflammatory responses
- Promotes angiogenesis
- Improved stability and resistance to enzymatic degradation
- Useful in research for infection-related diseases and wound healing
- Effective against Gram-positive and Gram-negative bacteria
Medchemexpress LLC BIM 23042 (trifluoroacetate) | 00-00-0 | MFCD32666112 | 96.2% | 1192.45 g/mol | C63H73N11O9S2·xC2HF3O2 | 1 MG
BIM 23042 (trifluoroacetate) is a somatostatin-like octapeptide analogue that acts as a selective neuromedin B receptor (NMB-R/BB1) antagonist. It is supplied as the trifluoroacetate salt in solid form for research use in receptor pharmacology and intracellular calcium signaling studies.
- Selective neuromedin B receptor (NMB-R/BB1) antagonist.
- Somatostatin-like octapeptide structure as the trifluoroacetate salt.
- Purity approximately 96.2% by supplier analysis.
- White to off-white solid powder suitable for laboratory use.
- Store sealed away from moisture and light; powder stable at -80°C (2 years) or -20°C (1 year).
Medchemexpress LLC AS-99 TFA | 99.2% | C29H31F6N5O5S2 | 1 ML
AS-99 TFA is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor with anti-leukemic activity. It blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. The compound has an IC50 of 0.79 μM and a Kd of 0.89 μM for ASH1L.
- First-in-class, potent, and selective ASH1L histone methyltransferase inhibitor.
- Exhibits anti-leukemic activity.
- Blocks cell proliferation.
- Induces apoptosis and differentiation.
- Downregulates MLL fusion target genes.
- Reduces leukemia burden in vivo.
- Selective for ASH1L, with no significant inhibition observed at 50 μM on a panel of 20 other histone methyltransferases.
Apexbio Technology LLC cyclo(RLsKDK) TFA(Synonyms: cyclo(RLsKDK), Cyclic peptide RLsKDK, ADAM8 inhibitor peptide, Cyclo-Arg-Leu-Ser-Lys-Asp-Lys), 1mg.
Cyclo(RLsKDK) TFA is a cyclic pentapeptide inhibitor targeting the metalloproteinase ADAM8 a transmembrane protein frequently dysregulated in pathological conditions such as inflammation cancer and neurodegenerative diseases By specifically inhibiting ADAM8 enzymatic activity cyclo(RLsKDK) TFA may modulate disease-associated cellular processes This molecule holds promise as a research tool for studying ADAM8 function and as a potential therapeutic candidate in inflammatory disorders and oncology
