Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Thanatin TFA | 99.7% | 2433.92 (free base) | 5 MG
Thanatin TFA is an inducible cationic antimicrobial peptide (AMP) with a single-disulfide-bond-containing β-hairpin structure. It exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria, as well as various fungal species. This peptide functions by competitively replacing divalent cations from the bacterial outer membrane, leading to its disruption.
- Exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria.
- Effective against various species of fungi.
- Disrupts bacterial outer membrane.
- Potent inhibitory effect on NDM-1-producing E. coli and K. pneumoniae strains.
- Increases survival rates and decreases bacterial titers in infected mice.
- Rescues pathological damages in a dose-dependent manner in vivo.
![Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384391-logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
Medchemexpress LLC Cyclorasin 9A5 (TFA) | 1 MG
Cyclorasin 9A5 (TFA) from MedChemExpress is a laboratory chemical intended for research use only. It is presented as a solid and is stable under recommended storage conditions, emphasizing careful handling and storage to maintain its integrity.
- Stable under recommended storage
- Keep sealed in cool, well-ventilated area, away from direct sunlight and ignition
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Solution storage: -80°C for 6 months, -20°C for 1 month
- Ships at room temperature (less than 2 weeks)
- Not classified as hazardous
- Requires personal protective equipment (safety goggles, gloves, impervious clothing, respirator)
- Ensure adequate ventilation, safety shower, and eye wash station
Medchemexpress LLC Cys-PKHB1 TFA | 65.8% | 1487.88 | 1 MG
Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, which is a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. This peptide induces mitochondrial alterations, ROS generation, intracellular Ca+ accumulation, and calcium-dependent cell death in breast cancer cells. It also induces immune system activation in breast cancer cells through immunogenic cell death.
- Peptide conjugated to PKHB1
- Acts as a CD47 agonist
- Functions as a thrombospondin-1 peptide mimic
- Induces mitochondrial alterations
- Promotes ROS generation
- Leads to intracellular Ca+ accumulation
- Causes calcium-dependent cell death in breast cancer cells
- Induces immune system activation in breast cancer cells
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 100 UG
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Tetrapeptide
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Huwentoxin-IV TFA | 105856-78-4 | 99.04% | 4099.71 | 5 MG
Huwentoxin-IV TFA is a highly potent and selective blocker of neuronal voltage-gated sodium channels. It specifically inhibits NaV1.7 activity in human DRG neurons.
- Potent and selective sodium channel blocker
- Inhibits neuronal NaV1.7, NaV1.2, NaV1.3, and NaV1.4 channels
- IC50 of 2.9 nM for inhibiting NaV1.7-mediated currents
- Reduces NaV1.7 current amplitude by 50% at 0.5 nM
Medchemexpress LLC LARLLT (TFA) | 99.9% | 799.88 | 5 MG
LARLLT (TFA) is an EGFR-binding peptide with potential for research into EGFR overexpressing cancers, including lung, ovarian, and colorectal cancer.
- EGFR-binding peptide
- Potential for research of EGFR overexpressing cancers
- Targets EGFR
- Involves JAK/STAT signaling and protein tyrosine kinase/RTK pathways
- Sequence: Leu-Ala-Arg-Leu-Leu-Thr
- Molecular weight of 799.88
- Purity of 99.9% (HPLC)
- Soluble in DMSO: 50 mg/mL
- Appears as a white to off-white solid
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture)
Medchemexpress LLC CPN-351 TFA | 912.11 (free base) | 5 MG
CPN-351 TFA, a pentapeptide, acts as a selective antagonist for human NMUR1, demonstrating a pA2 of 7.35. Its antagonistic effect on human NMUR1 is significantly higher, specifically 10 times greater, than its effect on NMUR2. This compound is suitable for application in inflammation research.
- Selective antagonist of human NMUR1.
- Pentapeptide compound.
- Antagonistic effect on human NMUR1 is 10 times higher than on NMUR2.
- Used in the study of inflammation.
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | 98.74% | 4907.48 | 5 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. This compound is used in antidiabetic research and is for research use only. It is orally active and can also be administered by injection.
- Dual GIP and GLP-1 receptor agonist
- Orally active
- Can be administered by injection
- Suitable for antidiabetic research
Medchemexpress LLC LAGIPRA peptide (TFA) | 98.2% | 5756.50 (free base) | 5 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist that enhances insulin sensitivity by augmenting glucose disposal. It also reduces branched-chain amino acids (BCAAs) and ketoacids, making it a potential subject for research into type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity by augmenting glucose disposal
- Reduces branched-chain amino acids (BCAAs) and ketoacids
- Potential for research into type 2 diabetes
Medchemexpress LLC PKA RII peptide TFA | 99.7% | 2226.37 | 10 MG
PKA RII peptide TFA is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity. It is for research use only.
- Solid appearance, white to off-white color.
- Sequence: Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-R-Val-Ser-Val-Ala-Ala-Glu.
- Sequence shortening: DLDVPIPGRFDRRVSVAAE.
- Store as powder at -80°C for 2 years or -20°C for 1 year.
- Store in solvent at -80°C for 6 months or -20°C for 1 month (sealed storage, away from moisture).
- Soluble in H2O at 25 mg/mL (11.23 mM, requires ultrasonic).
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 1 MG
L2P4 TFA is a peptide-based, EBNA1 targeting fluorescent probe. It works by inhibiting EBNA1 homodimer formation, which selectively inhibits EBV+ tumor growth. It shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based, EBNA1 targeting fluorescent probe
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM
- Molecular weight: 1961.83 (free base)
- Appearance: Solid
- Color: Purple to purplish red
- Soluble in DMSO at 50 mg/mL
Medchemexpress LLC aStAx-35R TFA | 99.1% | 2392.86 | 1 MG
aStAx-35R TFA is a stapled peptide that functions as an antagonist of the nuclear form of β-catenin, thereby inhibiting Wnt signaling. It competitively prevents the binding of β-catenin to TCF4 and selectively induces growth inhibition in Wnt-dependent cancer cells.
- Directly targets and antagonizes the nuclear form of β-catenin.
- Effectively inhibits the Wnt signaling pathway.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition in cancer cells dependent on Wnt signaling.
Medchemexpress LLC Cpp12 (Tfa) | 98.69% | 1700.55 | 1 MG
CPP12 TFA is a small, amphiphilic, cyclic cell-penetrating peptide (CPP) in salt form. It binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and is then efficiently released from endosomes. It can be used for intracellular delivery of drugs and chemical probes.
- Small, amphiphilic, cyclic cell-penetrating peptide (CPP)
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficiently released from endosomes
- Can be used for intracellular delivery of drugs and chemical probes
Medchemexpress LLC Alpha-Melanocyte-Stimulating Hormone TFA | 171869-93-5 | 98.5% | 1 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
- Endogenous neuropeptide
- MC4R agonist with anti-inflammatory and antipyretic activities
- Post-translational derivative of pro-opiomelanocortin (POMC)
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells
- Modulates NFκB activation
- Inhibits translocation of transcription factor κB to the nucleus